Endocrine Abstracts

Results of several clinical studies have suggested that there is an excess risk of cardiovascular disease in persons with vitamin D deficiency.We examined association between serum levels of vitamin D - 25(OH)D and select cardiovascular risk factors in 254 postmenopausal women at a mean age of 55.38±205 years.Vitamin D levels, lipoproteins, TNF-α, Interleukin 6, adiponectin, insulin (using RIA methods) and glucose were as...

Introduction: Results of many studies indicate that the BsmI and FokI polymorphisms in the VDR gene may influence bone tissue metabolism and may be useful in means of identifying patients at greater risk of osteoporosis.Aim of the study: To determine frequency of polymorphic variants of VDR gene (BsmI and FokI) and its relationship to phenotypic features characterizing bone status (BMD).Materials and methods: 176 randomly selected ...

Multidimensional studies of medical aspects of ageing were performed in 6 provinces of Poland, the protocol included cross sectional analysis of thyroid function parameters.The sample was randomly chosen and included 4,051 respondents (49.2% females).Group consisted of 3,502 elderly subjects aged 65–90+y, divided into approximately equal six age subgroups; and 549 younger cohort, aged 55–59 y.Thyroi...

Pleiotropic effects of vit. D in the etiology of obesity, metabolic syndrome and diabetes are still debated. So far published reports considered only changes in vit D plasma level in individuals with obesity and diabetes, and did not take into account the role of polymorphisms in the vit. D receptor gene.The aim of the study was to evaluate obesity, carbohydrate and lipid metabolism and vitamin D level in two VDR polymorphisms (Fok and Bsm) in Polish agi...

The levels of bone turnover markers are elevated e.g. in osteoporosis, neoplastic diseases with bone involvement (e.g. myeloma). Recently bone markers have been found to play an important role in other diseases, like cardiovascular diseases (CVD). Vitamin D, which plays a role in body metabolism, is also an important hormone maintaining bone homeostasis.The aim of the study was to evaluate the levels of bone turnover markers (osteoprotegerin and ICTP) in...